SFRP4 promotes autophagy and blunts FSH responsiveness through inhibition of AKT signaling in ovarian granulosa cells

Abstract Background Secreted frizzled-related proteins (SFRPs) comprise a family of WNT signaling antagonists whose roles in the ovary are poorly understood. Sfrp4-null mice were previously found to be hyperfertile due to an enhanced granulosa cell response to gonadotropins, leading to decreased ant...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Michael Bérubé, Atefeh Abedini, Evelyne Lapointe, Samuel Gusscott, Julie Brind’Amour, Gustavo Zamberlam, Derek Boerboom
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	SFRP4 Granulosa cells Gonadotropins Autophagy KO mice Ovary
Online Access:	https://doi.org/10.1186/s12964-024-01736-1