BMAL1 upregulates STX17 levels to promote autophagosome-lysosome fusion in hippocampal neurons to ameliorate Alzheimer’s disease

Summary: We aim to investigate muscle ARNT-like protein 1 (BMAL1) regulation of syntaxin17 (STX17) in mouse hippocampal neurons, focusing on autophagy and amyloid-β (Aβ) deposition. Autophagosome-lysosome fusion in APP/PS1 hippocampal tissues was observed using transmission electron microscopy, whil...

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Bibliographic Details

Published in:	iScience
Main Authors:	Xiuya Zhou, Kaili Du, Tian Mao, Ning Wang, Lifei Zhang, Yuan Tian, Ting Liu, Li Wang, Xiaohui Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Subjects:	Neuroscience Molecular neuroscience Cellular neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224026385