DNA vaccines against GPRC5D synergize with PD-1 blockade to treat multiple myeloma

Abstract Multiple myeloma (MM), a hematological malignancy of the bone marrow, remains largely incurable. The orphan G protein-coupled receptor, GPRC5D, which is uniquely expressed in plasma cells and highly expressed in MM, is a compelling candidate for immunotherapy. In this study, we investigated...

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Bibliographic Details

Published in:	npj Vaccines
Main Authors:	Praveen Neeli, Perry Ayn Mayson A. Maza, Dafei Chai, Dan Zhao, Xen Ping Hoi, Keith Syson Chan, Ken H. Young, Yong Li
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Online Access:	https://doi.org/10.1038/s41541-024-00979-w