The role of miR-155-5p in inflammation and mechanical loading during intervertebral disc degeneration

Abstract Background Intervertebral disc (IVD) degeneration is a multifactorial pathological process resulting in the dysregulation of IVD cell activity. The catabolic shift observed in IVD cells during degeneration leads to increased inflammation, extracellular matrix (ECM) degradation, aberrant int...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Petra Cazzanelli, Mikkael Lamoca, Johannes Hasler, Oliver Nic Hausmann, Addisu Mesfin, Varun Puvanesarajah, Wolfgang Hitzl, Karin Wuertz-Kozak
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	MiRNA-155 Cyclic stretching ECM degradation MAPK signaling Degenerative disc disease Low back pain
Online Access:	https://doi.org/10.1186/s12964-024-01803-7