iPSC-Derived Gaucher Macrophages Display Growth Impairment and Activation of Inflammation-Related Cell Death

Gaucher disease is a lysosomal storage disorder characterized by β-glucosidase enzyme deficiency and substrate accumulation, especially in cells of the reticuloendothelial system. Typical features of the disease are the unrestrained activation of inflammatory mechanisms, whose molecular pathways are...

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Bibliographic Details

Published in:	Cells
Main Authors:	Daria Messelodi, Salvatore Nicola Bertuccio, Valentina Indio, Silvia Strocchi, Alberto Taddia, Salvatore Serravalle, Jessica Bandini, Annalisa Astolfi, Andrea Pession
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	Gaucher disease iPSC macrophages inflammation necroptosis
Online Access:	https://www.mdpi.com/2073-4409/10/11/2822