Adjuvants influence the maturation of VRC01-like antibodies during immunization

Summary: Once naive B cells expressing germline VRC01-class B cell receptors become activated by germline-targeting immunogens, they enter germinal centers and undergo affinity maturation. Booster immunizations with heterologous Envs are required for the full maturation of VRC01-class antibodies. He...

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Bibliographic Details

Published in:	iScience
Main Authors:	Maria L. Knudsen, Parul Agrawal, Anna MacCamy, K. Rachael Parks, Matthew D. Gray, Brittany N. Takushi, Arineh Khechaduri, Kelsey R. Salladay, Rhea N. Coler, Celia C. LaBranche, David Montefiori, Leonidas Stamatatos
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Subjects:	Biological sciences Immune response Immunology Virology
Online Access:	http://www.sciencedirect.com/science/article/pii/S258900422201745X