Human cytomegalovirus UL23 exploits PD-L1 inhibitory signaling pathway to evade T cell-mediated cytotoxicity

ABSTRACT Human cytomegalovirus (HCMV), a widely prevalent human beta-herpesvirus, establishes lifelong persistence in the host following primary infection. In healthy individuals, the virus is effectively controlled by HCMV-specific T cells and typically exhibits asymptomatic. The T cell immune resp...

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Bibliographic Details

Published in:	mBio
Main Authors:	Qin Yuan, Zhaosong Fan, Wenqiang Huang, Xiaoping Huo, Xiaoping Yang, Yanhong Ran, Jun Chen, Hongjian Li
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-07-01
Subjects:	human cytomegalovirus (HCMV) UL23 T cell cytotoxicity immune evasion IFN-γ PD-L1
Online Access:	https://journals.asm.org/doi/10.1128/mbio.01191-24