Cellular Membrane Localization of Innate Immune Checkpoint Molecule CD47 Is Regulated by Radixin in Human Pancreatic Ductal Adenocarcinoma Cells

In the past decade, immune checkpoint inhibitors have exhibited potent antitumor efficacy against multiple solid malignancies but limited efficacy against pancreatic ductal adenocarcinoma (PDAC). Cluster of differentiation (CD) 47, a member of the immunoglobulin G superfamily, is overexpressed in th...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Takuro Kobori, Yui Ito, Yuka Sawada, Yoko Urashima, Takuya Ito, Tokio Obata
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	innate immune checkpoint molecule CD47 ezrin/radixin/moesin pancreatic ductal adenocarcinoma cancer immunotherapy
Online Access:	https://www.mdpi.com/2227-9059/11/4/1117