Mechanism of SC targeting RhoA regulation and its potential value in gastric cancer therapy

RhoA drives the malignant progression of gastric cancer through cytoskeletal remodeling and the regulation of epithelial-mesenchymal transition (EMT). Here, we identified a novel small-molecule inhibitor, (E)-1,9-bis(3,4-dihydroxyphenyl)non-3-en-5-one (SC), targeting RhoA through molecular docking a...

Full description

Bibliographic Details

Published in:	Biochemistry and Biophysics Reports
Main Authors:	Haixiu Ma, Ping Jiang, Ronghua Ma, Jing Zhao, Qi Wang, Yonghua Xing, Chengzhu Cao, Zhanhai Su
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	Dual action Drug discovery RhoA inhibitor EMT Natural product
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580825002456