Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Abstract Neutrophil extracellular traps (NETs) are reticular structures released by neutrophils, and the process of their formation is called NETosis. NETs play a key role in the pathological process of sepsis. However, the specific regulatory mechanism has not been fully clarified. This study finds...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song
Format:	Article
Language:	English
Published:	Wiley 2025-09-01
Subjects:	Acod1 Neutrophil extracellular traps Neutrophils Sepsis Ubiquitination
Online Access:	https://doi.org/10.1002/advs.202411652