β-hydroxybutyrate resensitizes colorectal cancer cells to oxaliplatin by suppressing H3K79 methylation in vitro and in vivo

Abstract Background Ketone β-hydroxybutyrate (BHB) has been reported to prevent tumor cell proliferation and improve drug resistance. However, the effectiveness of BHB in oxaliplatin (Oxa)-resistant colorectal cancer (CRC) and the underlying mechanism still require further proof. Methods CRC-Oxa-res...

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Bibliographic Details
Published in:Molecular Medicine
Main Authors: Meng Deng, Peijie Yan, Hui Gong, Guiqiu Li, Jianjie Wang
Format: Article
Language:English
Published: BMC 2024-06-01
Subjects:
Colorectal cancer
Β-hydroxybutyrate
Oxaliplatin
Drug resistance
H3K79me
Online Access:https://doi.org/10.1186/s10020-024-00864-1

Internet

https://doi.org/10.1186/s10020-024-00864-1

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