Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness. Intriguingly, stem/progenitor cells maintaining repressed mitochondri...

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Bibliographic Details
Published in:eLife
Main Authors: Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Subjects:
mitochondrial fission
Drp1
stem/progenitor state
keratinocytes
neoplastic transformation
single cell confocal microscopy
Online Access:https://elifesciences.org/articles/68394

Internet

https://elifesciences.org/articles/68394

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