Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters

Pibrentasvir (PIB) has been demonstrated to block exonuclease activity of the SARS-CoV-2 polymerase, protecting favipiravir (FVP) and remdesivir (RDV) from post-incorporation excision and eliciting antiviral synergy in vitro. The present study investigated the chemoprophylactic efficacy of PIB, FVP,...

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出版年:	Viruses
主要な著者:	Eduardo Gallardo-Toledo, Megan Neary, Joanne Sharp, Joanne Herriott, Edyta Kijak, Chloe Bramwell, Paul Curley, Usman Arshad, Henry Pertinez, Rajith K. R. Rajoli, Anthony Valentijn, Helen Cox, Lee Tatham, Anja Kipar, James P. Stewart, Andrew Owen
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2023-10-01
主題:	SARS-CoV-2 pibrentasvir favipiravir remdesivir chemoprophylaxis
オンライン･アクセス:	https://www.mdpi.com/1999-4915/15/11/2161