Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib

Background Mutations of the BCR-ABL tyrosine kinase domain constitute a major cause of resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia. We sought to improve the diagnostic armamentarium by screening and to analyze the dynamics of mutated clones in chronic myeloid l...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Haematologica
المؤلفون الرئيسيون: Thomas Ernst, Philipp Erben, Martin C. Müller, Peter Paschka, Thomas Schenk, Jana Hoffmann, Sebastian Kreil, Paul La Rosée, Rüdiger Hehlmann, Andreas Hochhaus
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Ferrata Storti Foundation 2008-02-01
الوصول للمادة أونلاين:https://haematologica.org/article/view/4738