Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.

The rational design of amyloid oligomer inhibitors is yet an unmet drug development need. Previous studies have identified the role of tryptophan in amyloid recognition, association and inhibition. Furthermore, tryptophan was ranked as the residue with highest amyloidogenic propensity. Other studies...

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發表在:	PLoS ONE
Main Authors:	Roni Scherzer-Attali, Riccardo Pellarin, Marino Convertino, Anat Frydman-Marom, Nirit Egoz-Matia, Sivan Peled, Michal Levy-Sakin, Deborah E Shalev, Amedeo Caflisch, Ehud Gazit, Daniel Segal
格式:	Article
語言:	英语
出版:	Public Library of Science (PLoS) 2010-06-01
在線閱讀:	https://doi.org/10.1371/journal.pone.0011101