Plasma apolipoprotein A-I is a causal protective factor in sepsis

Abstract Apolipoprotein AI (ApoAI), the main component of high-density lipoprotein (HDL), binds pathogen lipids to limit inflammation. We performed a retrospective analysis of 442,601 European patients in the UK Biobank (UKB) cohort focused on sepsis patients (n = 11,643). We tested for a causal con...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Kyle R. Campbell, Kantimas Sitthikool, Kelly Roveran Genga, Nozomi Takahashi, Gary Zhu, Tadanaga Shimada, Taka-aki Nakada, John H. Boyd, James A. Russell, Keith R. Walley
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-09-01
Subjects:	Sepsis Lipopolysaccharides High density lipoprotein Apolipoprotein A-I Causality
Online Access:	https://doi.org/10.1038/s41598-025-19204-2