Impact of Fusobacterium nucleatum on immune cell interactions and gene expression in colorectal cancer: a retrospective cohort study

BackgroundColorectal cancer (CRC) is a major global health concern. The presence of Fusobacterium nucleatum (Fn) in CRC can promote cancer progression by modulating the immune response and creating an immunosuppressive environment.MethodsA cohort of 107 patients with localized CRC treated between 20...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Ronald Heregger, Florian Huemer, Richard Greil, Marina Canadas-Ortega, Gernot Posselt, Marieke E Ijsselsteijn, Christina Plattner, Dietmar Rieder, Zlatko Trajanoski, Anne Krogsdam, Eckhard Klieser, Daniel Neureiter, Silja Wessler, Lukas Weiss
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	colorectal cancer microbiota Fusobacterium nucleatum tumor microenvironment RNA-Seq immunosuppressive environment
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1629014/full