Targeting mesothelin-CD24 axis repolarizes tumor-associated macrophages to potentiate PD-1 blockade therapy in high-grade serous ovarian cancer

Background High-grade serous ovarian cancer (HGSOC) is a highly aggressive malignancy marked by an immunosuppressive tumor microenvironment that hinders effective immune responses. A key feature of this environment is the extensive infiltration of myeloid cells, which contributes to immune evasion....

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Bibliographic Details

Published in:	Journal for ImmunoTherapy of Cancer
Main Authors:	Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Haiou Liu, Chenyang Wang, Kankan Cao, Yujing Zhong, Xueling Wang, Xuyao Xu
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2025-02-01
Online Access:	https://jitc.bmj.com/content/13/2/e011230.full