Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission

ABSTRACT Simian immunodeficiency viruses (SIVs) have crossed from apes to humans at least four times, but only one event gave rise to the AIDS pandemic. The host barriers that pandemic HIV-1 group M (major) strains overcame to spread efficiently in humans remain poorly understood. To identify such b...

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Bibliographic Details

Published in:	Journal of Virology
Main Authors:	Qinya Xie, Qingxing Wang, Sabrina Noettger, Guillermo Gosálbez, Annika C. Betzler, Meta Volcic, Dorota Kmiec, Stefan Krebs, Alexander Graf, Dila Gülensoy, Gilbert Weidinger, Konstantin M. J. Sparrer, Frank Kirchhoff
Format:	Article
Language:	English
Published:	American Society for Microbiology 2026-06-01
Subjects:	SIVcpz replication-competent CRISPR screen IFITM2 PCED1B MEFV AXIN1
Online Access:	https://journals.asm.org/doi/10.1128/jvi.00314-26