Comparison of the pharmacokinetic and pharmacodynamic properties of two recombinant granulocyte colony-stimulating factor formulations after single subcutaneous administration to healthy volunteers

Background and objective: The aim of this randomized, single dose, two-period crossover study with two weeks wash-out period was the demonstration of bioequivalence of two recombinant human granulocyte colony-stimulating factor (rG-CSF) formulations after subcutaneous administration of 300 μg compar...

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Bibliographic Details

Published in:	Medicina
Main Authors:	Audrius Sveikata, Gintautas Gumbrevičius, Kastytis Šeštakauskas, Rima Kregždytė, Vytautas Janulionis, Vidmantas Fokas
Format:	Article
Language:	English
Published:	MDPI AG 2014-01-01
Subjects:	Human granulocyte colony-stimulating factor Biosimilarity Pharmacokinetics Pharmacodynamics Safety
Online Access:	http://www.sciencedirect.com/science/article/pii/S1010660X14000500