Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities

Abstract Background Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Of the three, HAS1 is found to be localized more into the cytoplasmic space where it synthesizes intracellular HA. HA is a ubiquitous glycosaminoglycan...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Cell Communication and Signaling
المؤلفون الرئيسيون: Nguyet Nguyen, Awanit Kumar, Simi Chacko, Rodney J. Ouellette, Anirban Ghosh
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2017-11-01
الموضوعات:
Hyaluronic acid Synthase-1
Malignant transformation
Epithelial-to-Mesenchymal transition
Genetic heterogeneity
Genomic instability
Micronucleus
الوصول للمادة أونلاين:http://link.springer.com/article/10.1186/s12964-017-0204-z

الانترنت

http://link.springer.com/article/10.1186/s12964-017-0204-z

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