Oncogenic PIK3CA corrupts growth factor signaling specificity

Abstract Technical limitations have prevented understanding of how growth factor signals are encoded in distinct activity patterns of the phosphoinositide 3-kinase (PI3K)/AKT pathway, and how this is altered by oncogenic pathway mutations. We introduce a kinetic, single-cell framework for precise ca...

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Bibliographic Details
Published in:Molecular Systems Biology
Main Authors: Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck
Format: Article
Language:English
Published: Springer Nature 2024-12-01
Subjects:
PI3K Signaling Dynamics
Information Transfer
Growth Factor Specificity
Single-cell Biology
Online Access:https://doi.org/10.1038/s44320-024-00078-x

Internet

https://doi.org/10.1038/s44320-024-00078-x

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