Inhibition of Neddylation Suppresses Osteoclast Differentiation and Function In Vitro and Alleviates Osteoporosis In Vivo

Neddylation, or the covalent addition of NEDD8 to specific lysine residue of proteins, is a reversible posttranslational modification, which regulates numerous biological functions; however, its involvement and therapeutic significance in osteoporosis remains unknown. Our results revealed that durin...

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書誌詳細

出版年:	Biomedicines
主要な著者:	Meng-Huang Wu, Wei-Bin Hsu, Mei-Hsin Chen, Chung-Sheng Shi
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2022-09-01
主題:	neddylation osteoclast differentiation osteoporosis NEDD8-activating enzyme MLN4924
オンライン･アクセス:	https://www.mdpi.com/2227-9059/10/10/2355