TRPC3 determines osmosensitive [Ca2+]i signaling in the collecting duct and contributes to urinary concentration.

It is well-established that the kidney collecting duct (CD) plays a central role in regulation of systemic water homeostasis. Aquaporin 2 (AQP2)-dependent water reabsorption in the CD critically depends on the arginine vasopressin (AVP) antidiuretic input and the presence of a favorable osmotic grad...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Viktor N Tomilin, Mykola Mamenko, Oleg Zaika, Guohui Ren, Sean P Marrelli, Lutz Birnbaumer, Oleh Pochynyuk
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0226381