p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.

<h4>Background</h4>The p53 tumor suppressor, which is altered in most cancers, is a sequence-specific transcription factor that is able to modulate the expression of many target genes and influence a variety of cellular pathways. Inactivation of the p53 pathway in cancer frequently occur...

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書誌詳細

出版年:	PLoS ONE
主要な著者:	Virginia Andreotti, Yari Ciribilli, Paola Monti, Alessandra Bisio, Mattia Lion, Jennifer Jordan, Gilberto Fronza, Paola Menichini, Michael A Resnick, Alberto Inga
フォーマット:	論文
言語:	英語
出版事項:	Public Library of Science (PLoS) 2011-01-01
オンライン･アクセス:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020643&type=printable