NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

Abstract As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model overexpressing the ACE2 receptor (ACE2-OE) that suppo...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Camille R. Simoneau, Pei-Yi Chen, Galen K. Xing, Jennifer M. Hayashi, Irene P. Chen, Mir M. Khalid, Nathan L. Meyers, Taha Y. Taha, Kristoffer E. Leon, Rahul K. Suryawanshi, Maria McCavitt-Malvido, Tal Ashuach, Krystal A. Fontaine, Lauren Rodriguez, Bastian Joehnk, Keith Walcott, Sreelakshmi Vasudevan, Xiaohui Fang, Mazharul Maishan, Shawn Schultz, Jeroen P. Roose, Michael A. Matthay, Anita Sil, Mehrdad Arjomandi, Nir Yosef, Melanie Ott
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-07-01
Online Access:	https://doi.org/10.1038/s41598-024-66003-2