A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 p...

Full description

Bibliographic Details

Published in:	Cell Reports
Main Authors:	Annabelle Lewis, Luke Freeman-Mills, Elisa de la Calle-Mustienes, Rosa María Giráldez-Pérez, Hayley Davis, Emma Jaeger, Martin Becker, Nina C. Hubner, Luan N. Nguyen, Jorge Zeron-Medina, Gareth Bond, Hendrik G. Stunnenberg, Jaime J. Carvajal, Jose Luis Gomez-Skarmeta, Simon Leedham, Ian Tomlinson
Format:	Article
Language:	English
Published:	Elsevier 2014-08-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124714005890