PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration

Rotenone, a widely used pesticide, causes dopaminergic neurons loss and increase the risk of Parkinson's disease (PD). However, few studies link the role of PARP1 to neuroinflammatory response and autophagy dysfunction in rotenone-induced neurodegeneration. Here, we identified that PARP1 overac...

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發表在:	Ecotoxicology and Environmental Safety
Main Authors:	He Zhang, Zhefan Xie, Yongming Peng, Ailun Xie, Chunlai Fu, Dongyan Zheng, ZiWei Cai, Jiahong Zhong, Qiang Ming, Mingque Li, Renjian Lu, Xin Liu, Jialong Chen
格式:	Article
語言:	英语
出版:	Elsevier 2023-03-01
主題:	Rotenone PARP1 TFEB Autophagy NLRP3
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S0147651323001343