Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction

Toosendanin (TSN) is a triterpenoid from the fruit or bark of <i>Melia toosendan</i> Sieb et Zucc, which has clear antitumor and insecticidal activities, but it possesses limiting hepatotoxicity in clinical application. Autophagy is a degradation and recycling mechanism to maintain cellu...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Li Luo, Yonghong Liang, Yuanyuan Fu, Zhiyuan Liang, Jinfen Zheng, Jie Lan, Feihai Shen, Zhiying Huang
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	toosendanin (TSN) hepatotoxicity autophagy autophagic flux lysosome TFEB
Online Access:	https://www.mdpi.com/1424-8247/15/12/1509