Genetic modification of mammalian genome at chromosome level

The review is concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo at chromosomal level. Recently three new approaches for the chromosome biotechnology have been developed: Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole...

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Bibliographic Details

Published in:	Anais da Academia Brasileira de Ciências
Main Authors:	OLEG L. SEROV, NATALIA M. MATVEEVA, IRINA A. SEROVA, PAVEL M. BORODIN
Format:	Article
Language:	English
Published:	Academia Brasileira de Ciências 2000-09-01
Subjects:	chromosome biotechnology Cre/loxP ES cells MAC
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300012