Phase II trial of nivolumab and metformin in patients with treatment-refractory microsatellite stable metastatic colorectal cancer

Background Preclinical studies showed metformin reduces exhaustion of tumor-infiltrating lymphocytes and potentiates programmed cell death protein-1 (PD-1) blockade. We hypothesized that metformin with nivolumab would elicit potent antitumor and immune modulatory activity in metastatic microsatellit...

Full description

Bibliographic Details

Published in:	Journal for ImmunoTherapy of Cancer
Main Authors:	Gregory B Lesinski, Christina Wu, Mehmet Akce, Brian Olson, Maria Diab, Batoul Farran, Jeffrey M Switchenko, Manali Rupji, Sandra Kang, Lana Khalil, Amanda Ruggieri-Joyce, Walid L Shaib, Olatunji B Alese, Bassel F El-Rayes
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2023-10-01
Online Access:	https://jitc.bmj.com/content/11/10/e007235.full