Defying the stereotype: non-canonical roles of the peptide hormones guanylin and uroguanylin

The peptide hormones uroguanylin and guanylin have been traditionally thought to be mediators of fluid-ion homeostasis in the vertebrate intestine. They serve as ligands for receptor guanylyl cyclase C (GC-C), and both receptor and ligands are expressed predominantly in the intestine. Ligand binding...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Nirmalya eBasu, Sandhya Srikant Visweswariah
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2011-06-01
Subjects:	cGMP GC-C GC-D Guanylin receptor guanylyl cyclase uroguanylin
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00014/full