Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

Abstract Background Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleaved into individual granulin peptides, which are inc...

Full description

Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson, Aimee W. Kao
Format:	Article
Language:	English
Published:	BMC 2021-08-01
Subjects:	Progranulin Granulin Frontotemporal lobar degeneration Lysosome Protease pH
Online Access:	https://doi.org/10.1186/s13024-021-00472-1