A systematic review and meta-analysis of noradrenaline compared to adrenaline in the management of septic shock

Background: Septic shock is associated with significant mortality. The International Surviving Sepsis Campaign guidelines recommend noradrenaline as first-line vasopressor, whilst South African guidelines recommend adrenaline. Clinical trials show similar efficacy but suggest safety advantages for n...

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Bibliographic Details

Published in:	African Journal of Emergency Medicine
Main Authors:	Trudy D Leong, Rephaim Mpofu, Sumaya Dadan, Karen Cohen, Halima Dawood, Tamara Kredo, Andy Parrish, Marc Blockman, P. Dean Gopalan
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	Septic shock Adrenaline Noradrenaline Mortality Dysrhythmias Lactate
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211419X25000205