The avermectin, emamectin benzoate, kills gram-positive bacteria and targets the cell envelope of Bacillus subtilis

ABSTRACT The avermectin family of anthelmintics is largely considered to lack antibacterial activity against gram-positive and gram-negative bacteria. Here, we screened six avermectins (ivermectin, eprinomectin, doramectin, abamectin, selamectin, and emamectin benzoate) and a structurally related mi...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Rabih Ahmad, Drew Lewis, Lou Ann Verellen, Raymond Yin, Andrew Scott, Michael Fruci
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-10-01
Subjects:	avermectin milbemycin Bacillus subtilis antibacterials cell envelope stress response emamectin benzoate
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.00274-25