Be Aware of Aggregators in the Search for Potential Human ecto-5′-Nucleotidase Inhibitors

Promiscuous inhibition due to aggregate formation has been recognized as a major concern in drug discovery campaigns. Here, we report some aggregators identified in a virtual screening (VS) protocol to search for inhibitors of human ecto-5′-nucleotidase (ecto-5′-NT/CD73), a promi...

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Bibliographic Details
Published in:Molecules
Main Authors: Lucas G. Viviani, Erika Piccirillo, Arquimedes Cheffer, Leandro de Rezende, Henning Ulrich, Ana Maria Carmona-Ribeiro, Antonia T.-do Amaral
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Subjects:
aggregation
promiscuous mechanism
human ecto-5′-nucleotidase
virtual screening
enzymatic assays
turbidimetry
dynamic light scattering
Online Access:http://www.mdpi.com/1420-3049/23/8/1876

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http://www.mdpi.com/1420-3049/23/8/1876

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