Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome

Abstract Background Acute radiation syndrome (ARS) manifests after exposure to high doses of radiation in the instances of radiologic accidents or incidents. Facilitating regeneration of the bone marrow (BM), namely the hematopoietic stem and progenitor cells (HSPCs), is key in mitigating ARS and mu...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Justin Vercellino, Beata Małachowska, Shilpa Kulkarni, Brett I. Bell, Shahin Shajahan, Kosaku Shinoda, Gary Eichenbaum, Amit K. Verma, Sanchita P. Ghosh, Weng-Lang Yang, Paul S. Frenette, Chandan Guha
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Subjects:	Hematopoietic acute radiation syndrome Total body irradiation Bone marrow Mesenchymal stromal cells Endothelial cells Thrombopoietin mimetic
Online Access:	https://doi.org/10.1186/s13287-024-03734-z