SPOP mutations increase PARP inhibitor sensitivity via CK2/PIAS1/SPOP axis in prostate cancer

It is well documented that impaired DNA damage repair (DDR) induces genomic instability that can efficiently increase the sensitivity of prostate cancer (PCa) cells to PARP inhibitors; however, the underlying mechanism remains elusive. Here, we found profound genomic instability in PCa cells with SP...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:JCI Insight
المؤلفون الرئيسيون: Hui Zhang, Lili Kong, Jinhui Li, Zhihan Liu, Yiting Zhao, Xiuyi Lv, Liangpei Wu, Lin Chai, Hongjie You, Jiabei Jin, Xinyi Cao, Zhong Zheng, Yadong Liu, Zejun Yan, Xiaofeng Jin
التنسيق: مقال
اللغة:الإنجليزية
منشور في: American Society for Clinical investigation 2025-04-01
الموضوعات:
Cell biology
Genetics
Oncology
الوصول للمادة أونلاين:https://doi.org/10.1172/jci.insight.186871

الانترنت

https://doi.org/10.1172/jci.insight.186871

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