Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice

Osteoclasts are essential for bone remodeling by adapting their resorptive activity in response to their mechanical in vivo environment. However, the molecular mechanisms underlying this process remain unclear. Here, we demonstrated the role of tartrate-resistant acid phosphatase (TRAP, Acp5), a key...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Dilara Yılmaz, Francisco C. Marques, Yannick Fischer, Sandra Zimmermann, Gaonhae Hwang, Penny R. Atkins, Neashan Mathavan, Amit Singh, Pedro P.C. de Souza, Gisela A. Kuhn, Esther Wehrle, Ralph Müller
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Mechanosensitivity CRISPR/Cas9 mediated reporter mice Fluorescent osteoclasts and osteoblasts TRAP deficiency Trabecular bone remodeling Micro-computed tomography
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024089801