Human iPSC-derived motor neurons as a platform for elucidating TDP-43-related amyotrophic lateral sclerosis pathogenesis: a mini review

TAR DNA-binding protein 43 (TDP-43) is a major pathogenic RNA-binding protein associated with amyotrophic lateral sclerosis (ALS). Heterozygous mutations in TDP-43 cause familial ALS, known as ALS10. TDP-43 is predominantly localized in the nucleus under physiological conditions. Not only ALS patien...

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書誌詳細

出版年:	Frontiers in Molecular Neuroscience
主要な著者:	Satoshi Yokoi, Yohei Iguchi, Masahisa Katsuno
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2026-05-01
主題:	amyotrophic lateral sclerosis co-culture iPSC-derived motor neuron RNA-binding protein TDP-43
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fnmol.2026.1864964/full