Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

Summary: Although mutations in several genes with diverse functions have been known to cause amyotrophic lateral sclerosis (ALS), it is unknown to what extent causal mutations impinge on common pathways that drive motor neuron (MN)-specific neurodegeneration. In this study, we combined induced pluri...

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Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Akshay Bhinge, Seema C. Namboori, Xiaoyu Zhang, Antonius M.J. VanDongen, Lawrence W. Stanton
Format:	Article
Language:	English
Published:	Elsevier 2017-04-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671117300863