Whole-Body Physiologically Based Pharmacokinetic–Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs

<b>Introduction/aim:</b> N-acetylgalactoseamine-conjugated small interfering RNAs (GalNAc-siRNAs) are an emerging class of drugs possessing an extensive clinical potential because of their high target specificity to the asialoglycoprotein receptor (ASGPR) in hepatocytes. Overall, GalNAc-...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Emilie Langeskov Salim, Kim Kristensen, Girish Chopda, Erik Sjögren
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	GalNAc-siRNA physiologically based pharmacokinetic modeling PK-Sim species translation
Online Access:	https://www.mdpi.com/1999-4923/17/9/1154