Trem2 Enhances Demyelination in the <i>Csf1r</i>^+/− Mouse Model of Leukoencephalopathy

Colony-stimulating factor-1 receptor (CSF-1R)-related leukoencephalopathy (CRL) is a neurodegenerative disease that triggers early demyelination, leading to an adult-onset dementia. Triggering receptor expressed on myeloid cells-2 (TREM2) is a microglial receptor that promotes the activation of micr...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Fabrizio Biundo, Violeta Chitu, Şölen Gökhan, Edward Chen, Jude Oppong-Asare, E. Richard Stanley
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	HDLS ALSP CSF-1 receptor TREM2 demyelination corpus callosum
Online Access:	https://www.mdpi.com/2227-9059/11/8/2094