KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification

IntroductionIntegrating immune repertoire sequencing data with single cell sequencing data offers profound insights into the diversity of immune cells and their dynamic changes across various disease states.MethodsHere, we propose a novel KDDC framework that integrates kmers, dataset selection, dime...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Nan Zhang, Shishun Zhao, Runze Wu, Xizi Luo, Ming Yang, Zecheng Chang, Jianting Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	KDDC immune repertoire cdr3aa structural similarity immune cell heterogeneity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1602907/full