Association and multimodal model of retinal and blood-based biomarkers for detection of preclinical Alzheimer’s disease

Abstract Background The potential diagnostic value of plasma amyloidogenic beta residue 42/40 ratio (Aβ42/Aβ40 ratio), neurofilament light (NfL), tau phosphorylated at threonine-181 (p-tau181), and threonine-217 (p-tau217) has been extensively discussed in the literature. We have also previously des...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Swetha Ravichandran, Peter J. Snyder, Jessica Alber, Charles F. Murchison, Lauren E. Chaby, Andreas Jeromin, Edmund Arthur
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Subjects:	Putative retinal gliosis Plasma biomarkers Preclinical Alzheimer’s disease Early detection Spectral domain optical coherence tomography
Online Access:	https://doi.org/10.1186/s13195-024-01668-5