Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma

Abstract Background Ring finger proteins (RNFs) were involved in carcinogenesis. Here, we aimed to explore the detailed mechanism of RNF128 in the progression of melanoma. Methods We reanalyzed several gene expression profiles from the Gene Expression Omnibus (GEO) database and obtained the overlapp...

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Bibliographic Details
Published in:Journal of Hematology & Oncology
Main Authors: Chuan-Yuan Wei, Meng-Xuan Zhu, Yan-Wen Yang, Peng-Fei Zhang, Xuan Yang, Rui Peng, Chao Gao, Jia-Cheng Lu, Lu Wang, Xin-Yi Deng, Nan-Hang Lu, Fa-Zhi Qi, Jian-Ying Gu
Format: Article
Language:English
Published: BMC 2019-03-01
Subjects:
RNF128
Melanoma
EMT
Prognosis
Wnt signaling
Online Access:http://link.springer.com/article/10.1186/s13045-019-0711-z

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http://link.springer.com/article/10.1186/s13045-019-0711-z

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