The Role of IRF8 Polymorphisms in Systemic Sclerosis Development and Pathogenesis

Systemic sclerosis (SSc) is a rare autoimmune disease whose molecular mechanisms are not yet fully understood. There is no definitive cure, and the main causes of death are pulmonary fibrosis and pulmonary arterial hypertension. Here, we focus on the interferon regulators factor 8 (IRF8), a factor i...

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Bibliographic Details

Published in:	Journal of Molecular Pathology
Main Authors:	Anna Mennella, Giuseppe Ocone, Katia Stefanantoni, Loredana Frasca
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Subjects:	systemic sclerosis (SSc) interferon regulatory factor 8 (IRF8) diffuse cutaneous (dcSSc) limited cutaneous (lcSSc) interferon-I (INF-I) single nucleotide polymorphism (SNPs)
Online Access:	https://www.mdpi.com/2673-5261/5/1/8