Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis

Background: Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand the characteristic immunopathology of tuberculosis. We performed targeted metabolomic analyses in a large cohort of patients with tuberculous meningitis (TBM), the...

Full description

Bibliographic Details

Published in:	eLife
Main Authors:	Edwin Ardiansyah, Julian Avila-Pacheco, Le Thanh Hoang Nhat, Sofiati Dian, Dao Nguyen Vinh, Hoang Thanh Hai, Kevin Bullock, Bachti Alisjahbana, Mihai G Netea, Riwanti Estiasari, Trinh Thi Bich Tram, Joseph Donovan, Dorothee Heemskerk, Tran Thi Hong Chau, Nguyen Duc Bang, Ahmad Rizal Ganiem, Rovina Ruslami, Valerie ACM Koeken, Raph L Hamers, Darma Imran, Kartika Maharani, Vinod Kumar, Clary B Clish, Reinout van Crevel, Guy Thwaites, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-05-01
Subjects:	tuberculous meningitis cerebrospinal fluid plasma metabolomics survival central nervous system
Online Access:	https://elifesciences.org/articles/85307