CAF-Associated Paracrine Signaling Worsens Outcome and Potentially Contributes to Chemoresistance in Epithelial Ovarian Cancer

BackgroundHigh-grade serous ovarian cancer (HGSOC) is the predominant and deadliest form of ovarian cancer. Some of its histological subtypes can be distinguished by frequent occurrence of cancer-associated myofibroblasts (CAFs) and desmoplastic stroma reaction (DSR). In this study, we want to explo...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Frontiers in Oncology
المؤلفون الرئيسيون:	Michael Wessolly, Elena Mairinger, Sabrina Borchert, Agnes Bankfalvi, Pawel Mach, Kurt Werner Schmid, Rainer Kimmig, Paul Buderath, Fabian Dominik Mairinger
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2022-03-01
الموضوعات:	tumor microenvironment epithelial ovarian cancer high-grade serous ovarian cancer cancer-associated fibroblasts chemoresistance
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fonc.2022.798680/full