Genetically modified E. Coli secreting melanin (E.melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson’s disease

Abstract The characteristic neuropathology of Parkinson’s disease (PD) involves the abnormal accumulation of phosphorylated α-synuclein (αSyn), as well as a significant decrease in neuromelanin (NM) levels within dopamine neurons (DaNs). Unlike αSyn aggregates, the relationship between NM levels and...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Weixian Kong, Yu Liu, Pu Ai, Yong Bi, Chaoguang Wei, Xiaoyang Guo, Zhenyu Cai, Ge Gao, Peng Hu, Jialin Zheng, Jianhui Liu, Minfeng Huo, Yuting Guan, Qihui Wu
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Subjects:	Melanin Parkinson’s disease Dopamine neuron Astrocyte PSAP-GPR37L1 pathway
Online Access:	https://doi.org/10.1186/s12951-024-02955-x